abstract：:Major antioxidant responses to increased levels of inflammatory, oxidative and nitrosative stress (ONS) are detailed. In response to increasing levels of nitric oxide, S-nitrosylation of cysteine thiol groups leads to post-transcriptional modification of many cellular proteins and thereby regulates their activity and ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Morris G,Puri BK,Walker AJ,Berk M,Walder K,Bortolasci CC,Marx W,Carvalho AF,Maes M

更新日期：2019-12-20 00:00:00

abstract：:Cocaine dependence is a complex psychiatric disorder that is highly comorbid with other psychiatric traits. Twin and adoption studies suggest that genetic variants contribute substantially to cocaine dependence susceptibility, which has an estimated heritability of 65-79%. Here we performed a meta-analysis of genome-w...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cabana-Domínguez J,Shivalikanjli A,Fernàndez-Castillo N,Cormand B

更新日期：2019-08-30 00:00:00

abstract：:Neuronal apoptosis and impaired hippocampal neurogenesis are major players in cognitive/memory dysfunctions including Alzheimer's disease (AD). Interferon beta (IFNβ) is a cytokine with anti-apoptotic and neuroprotective properties on the central nervous system (CNS) cells which specifically affects neural progenitor ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Chavoshinezhad S,Mohseni Kouchesfahani H,Ahmadiani A,Dargahi L

更新日期：2019-08-30 00:00:00

abstract：:Tardive dyskinesia (TD) is an adverse movement disorder induced by chronic treatment with antipsychotics drugs. The contribution of common genetic variants to TD susceptibility has been investigated in recent years, but with limited success. The aim of the current study was to investigate the potential contribution of...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Alkelai A,Greenbaum L,Heinzen EL,Baugh EH,Teitelbaum A,Zhu X,Strous RD,Tatarskyy P,Zai CC,Tiwari AK,Tampakeras M,Freeman N,Müller DJ,Voineskos AN,Lieberman JA,Delaney SL,Meltzer HY,Remington G,Kennedy JL,Pulver AE,

更新日期：2019-08-30 00:00:00

abstract：:Electroacupuncture (EA) is a clinically useful physiological therapy that has been recently adopted to treat several brain disorders. However, the potential role of early EA intervention in the prevention of posttraumatic stress disorder (PTSD) as well as its potential cellular and molecular mechanism has never been i...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Xue F,Xue SS,Liu L,Sang HF,Ma QR,Tan QR,Wang HN,Zhou CH,Peng ZW

更新日期：2019-07-13 00:00:00

abstract：:There is accumulating neuroimaging evidence for both structural and functional abnormalities in schizophrenia patients with persistent auditory verbal hallucinations (AVH). So far, the direct interrelationships between altered structural and functional changes underlying AVH are unknown. Recently, it has become possib...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kubera KM,Rashidi M,Schmitgen MM,Barth A,Hirjak D,Sambataro F,Calhoun VD,Wolf RC

更新日期：2019-07-13 00:00:00

abstract：:S 47445 is a positive allosteric modulator of glutamate AMPA-type receptors that possesses procognitive, neurotrophic and enhancing synaptic plasticity properties. Its chronic administration promotes antidepressant- and anxiolytic-like effects in different rodent models of depression. We have evaluated the behavioral ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pilar-Cuellar F,Castro E,Bretin S,Mocaer E,Pazos Á,Díaz Á

更新日期：2019-07-13 00:00:00

abstract：:Drug abuse and addiction are overwhelming health problems mainly during adolescence. Based on a previous study of our research group, the rats that received modafinil (MD) during the adolescence showed less preference for amphetamine (AMPH) in adulthood. Our current hypothesis is that MD will show beneficial effects a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dias VT,Rosa HZ,D'avila LF,Vey LT,Barcelos RCS,Burger ME

更新日期：2019-06-08 00:00:00

abstract：:Accumulating evidence indicates that dopamine (DA) D3 receptor (DAD3R) antagonists appear highly promising in attenuating cocaine reward and relapse in preclinical models of addiction. In the present study, we investigated the effects of the selective DAD3R antagonist SB-277011-A on the reinstatement of cocaine-induce...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Guerrero-Bautista R,Do Couto BR,Hidalgo JM,Cárceles-Moreno FJ,Molina G,Laorden ML,Núñez C,Milanés MV

更新日期：2019-06-08 00:00:00

abstract：:Autism is a complex neurodevelopmental disorder with high heritability. Previous genome-wide association studies (GWAS) demonstrated that some single-nucleotide polymorphisms (SNPs) were significantly associated with autism, while other studies focusing on these GWAS hits showed inconsistent results. Besides, the asso...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang Z,Zhang J,Lu T,Zhang T,Jia M,Ruan Y,Zhang D,Li J,Wang L

更新日期：2019-06-08 00:00:00

abstract：:Sensitization of motor activity is a behavioural test to evaluate the effects of psychostimulants. Conditioned place preference (CPP) is an associative learning procedure to examine the rewarding properties of drugs. We aimed to assess whether motor sensitization to drugs of abuse can make zebrafish more vulnerable to...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pisera-Fuster A,Rocco L,Faillace MP,Bernabeu R

更新日期：2019-06-08 00:00:00

abstract：:Major depression is the most common mental disorder and a leading cause of years lived with disability. In addition to the burden attributed to depressive symptoms and reduced daily life functioning, people with major depression are at increased risk of premature mortality, particularly due to cardiovascular diseases....

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kahl KG,Stapel B,Frieling H

更新日期：2019-03-08 00:00:00

abstract：:Alzheimer's disease (AD) by progressive neurodegenerative pattern is associated with autophagy stress which is suggested as a potential cause of amyloid β (Aβ) aggregation and neural loss. Apelin-13, a neuropeptide with modulatory effect on autophagy, has been shown the beneficial effects on neural cell injuries. We i...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Aminyavari S,Zahmatkesh M,Farahmandfar M,Khodagholi F,Dargahi L,Zarrindast MR

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:Intent-to-treat analyses from a randomized controlled trial showed significant between-group differences favouring micronutrient treatment on the Clinical Global Impression-Improvement, but no group differences on clinician, parent and teacher ratings of overall ADHD symptoms. There was an advantage of micro...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rucklidge JJ,Eggleston MJF,Darling KA,Stevens AJ,Kennedy MA,Frampton CM

更新日期：2019-03-08 00:00:00

abstract：OBJECTIVE:Previous studies suggested likely mechanisms underlying the dysfunction of the default mode network (DMN) in schizophrenia. However, altered patterns of the intrinsic activity of the DMN in both deficit schizophrenia (DS) and non-deficit schizophrenia (NDS) patients, as well as the neurocognitive relationship...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zhou C,Yu M,Tang X,Wang X,Zhang X,Zhang X,Chen J

更新日期：2019-03-08 00:00:00

abstract：OBJECTIVE:Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the pr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kiser DP,Popp S,Schmitt-Böhrer AG,Strekalova T,van den Hove DL,Lesch KP,Rivero O

更新日期：2019-03-08 00:00:00

abstract：:The discipline of affective neuroscience is concerned with the neural bases of emotion and mood. The past decades have witnessed an explosion of research in affective neuroscience, increasing our knowledge of the brain areas involved in fear and anxiety. Besides the brain areas that are classically associated with emo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hilber P,Cendelin J,Le Gall A,Machado ML,Tuma J,Besnard S

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:It has been proposed that state-independent, or trait, neurobiological alterations across illness phases may contribute to the high recurrence of major depressive disorder (MDD). Although intrinsic brain network abnormalities have been implicated consistently in MDD neuropathology, MDD state-independent and ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dong D,Ming Q,Zhong X,Pu W,Zhang X,Jiang Y,Gao Y,Sun X,Wang X,Yao S

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:Schizophrenia (SZ) is a complex psychiatric disorder and the exact mechanisms that underpin SZ remain poorly understood despite decades of research. Genetic, epigenetic, and environmental factors are all considered to play a role. The importance of gut flora and its influence on the central nervous system ha...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zhuo C,Yao Y,Xu Y,Liu C,Chen M,Ji F,Li J,Tian H,Jiang D,Lin C,Chen C

更新日期：2019-03-02 00:00:00

abstract：:Schizophrenia is a disorder associated with cortical inhibition deficits. Transcranial direct current stimulation (tDCS) induces changes in cortical excitability in healthy subjects and individuals with neuropsychiatric disorders depending on the stimulation parameters. Our aim was to investigate whether a previously ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gordon PC,Valiengo LDCL,de Paula VJR,Galhardoni R,Ziemann U,de Andrade DC,Brunoni AR

更新日期：2019-03-02 00:00:00

abstract：:Autism spectrum disorder (ASD) is characterized by repetitive behaviors, impaired social communication and stereotyped interests, and often associated with dysregulations in innate/adaptive immune cells. IL-17A has been linked with abnormal behavioral patterns observed in autistic children and animal models of autism....

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Nadeem A,Ahmad SF,Attia SM,Al-Ayadhi LY,Bakheet SA,Al-Harbi NO

更新日期：2019-03-02 00:00:00

abstract：:Adolescence is a period of active development of stress regulatory neurocircuitry. As a consequence, mechanisms that control the responses to stress are not fully matured during this developmental period, which may result in vulnerability to chronic stress. We hypothesized that adolescent chronic stress would have neg...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cotella EM,Gómez AS,Lemen P,Chen C,Fernández G,Hansen C,Herman JP,Paglini MG

更新日期：2019-01-10 00:00:00

abstract：:Erythropoietin (EPO), a cytokine molecule, is best-known for its role in erythropoiesis. Preclinical studies have demonstrated that EPO has robust neuroprotective effects that appear to be independent of erythropoiesis. It is also being clinically tested for the treatment of neuropsychiatric illnesses due to its behav...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tiwari NK,Sathyanesan M,Schweinle W,Newton SS

更新日期：2019-01-10 00:00:00

abstract：:Organ transplantation has become a well-established treatment option in patients with end-stage organ diseases. Although quality of life has markedly improved, psychiatric disorders before and after transplantation are more frequent compared to the general population. Psychopharmacological treatment is recommended for...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kahl KG,Eckermann G,Frieling H,Hillemacher T

更新日期：2019-01-10 00:00:00

abstract：:The underlying mechanisms of autism and schizophrenia are poorly understood, partly due to a lack of dimension-specific research. Aberrant excitatory and inhibitory neurotransmission are implicated in both conditions, particularly in social dysfunction. This study investigates the extent to which the degree of autisti...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ford TC,Abu-Akel A,Crewther DP

更新日期：2019-01-10 00:00:00

abstract：BACKGROUND:Existing research typically focuses on only one domain of cognition with regard to fairness-theory of mind or executive function. However, children with High-functioning autism spectrum disorder (HF-ASD) are cognitively impaired in both domains. Moreover, little is known about fairness characteristics in chi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang Y,Xiao Y,Li Y,Chu K,Feng M,Li C,Qiu N,Weng J,Ke X

更新日期：2019-01-10 00:00:00

abstract：:Deficits in decoding and understanding facially expressed emotions occur commonly in persons with autism spectrum disorder (ASD), which contribute to the impairment of social communication that serves as one of its core diagnostic criteria. Research suggests that abnormalities of visual scanning of the face, activatio...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Deutsch SI,Raffaele CT

更新日期：2019-01-10 00:00:00

abstract：:Stress has multifaceted effects on pain. On the one hand, it is a powerful inhibitor of nociception and inflammation; on the other hand, it contributes to enhanced pathological states including the establishment and continuation of chronic pain. These seemingly paradoxical effects can be better understood by investiga...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Vachon-Presseau E

更新日期：2018-12-20 00:00:00

abstract：:The aversive experience we call "pain" results from the coordinated activation of multiple brain areas, commonly described as a "pain matrix". This is not a fixed arrangement of structures but rather a fluid system composed of several interacting networks: A 'nociceptive matrix' includes regions receiving input from a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Garcia-Larrea L,Bastuji H

更新日期：2018-12-20 00:00:00

abstract：:Chronic pain patients often complain of their "poor memory" and numerous studies objectively confirmed such difficulties in reporting working memory (WM) and long-term memory (LTM) dysfunctions. This paper provides a comprehensive review of the literature on memory impairment in chronic pain (CP) patients. Twenty-four...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mazza S,Frot M,Rey AE

更新日期：2018-12-20 00:00:00

abstract：:Stress seems to be an important risk factor in the beginning and continuing stages of cigarette tobacco smoking in humans. Considering that both of nicotine administration and stress exposure affect cognitive functions including memory formation, the aim of the present study was 1) to evaluate the effect of subcutaneo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Keshavarzian E,Ghasemzadeh Z,Rezayof A

更新日期：2018-08-30 00:00:00

abstract：:Stress exposure has been implicated in the development of mood disorders, although little is known about the lasting effects of repeated stress during the adolescent period on sex-specific differences in endocrine and plasticity-signaling responses in adulthood. Using a 10-day combinatory stress paradigm (postnatal da...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Azogu I,Liang J,Plamondon H

更新日期：2018-08-30 00:00:00

abstract：:We aimed to examine the effects of infertility treatments on the risk of Autism Spectrum Disorder (ASD). Data were from a representative national registry on 110,093 male live births in Israel (born: 1999-2008; and ASD: 975, 0.9%). Infertility treatments included In Vitro Fertilization (IVF), and five hormone treatmen...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Davidovitch M,Chodick G,Shalev V,Eisenberg VH,Dan U,Reichenberg A,Sandin S,Levine SZ

更新日期：2018-08-30 00:00:00

abstract：:Ketamine hydrochloride elicits potent psychotomimetic and neurobehavioural effects which make it incompatible with driving; however, the direct effect on driving performance is yet to be assessed. Using an open label, within-subjects protocol, 15 males and 5 females (mean age = 30.8 years) were administered three fixe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hayley AC,Green M,Downey LA,Stough CKK,Keane M,Shiferaw B,Kostakis P,Shehabi Y

更新日期：2018-08-30 00:00:00

abstract：INTRODUCTION:Little is known about perception of physical pain in schizophrenia (SZ). Some studies have suggested that patients with SZ may have an increased pain threshold, while others have suggested that patients with SZ may suffer from undetected and untreated high physical pain levels. The objectives of this study...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Fond G,Boyer L,Andrianarisoa M,Godin O,Bulzacka E,Berna F,Brunel L,Coulon N,Aouizerate B,Capdevielle D,Chereau I,D'amato T,Denizot H,Dubertret C,Dubreucq J,Faget C,Leignier S,Mallet J,Misdrahi D,Rey R,Lancon C,P

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Static and dynamic functional connectivity are being increasingly used to measure the effects of disease and a range of different interventions on brain networks. While preliminary evidence suggests that static connectivity can be modulated by chronic antidepressants administration in healthy individuals and...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Arnone D,Wise T,Walker C,Cowen PJ,Howes O,Selvaraj S

更新日期：2018-06-08 00:00:00

abstract：:Our objective was to examine the association between antipsychotic receptor binding profiles and the magnitude of common side-effects. We used regression analysis to examine the association between the receptor binding affinities of antipsychotic agents (log Ki) and degree of specific antipsychotic side-effects. Data ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Olten B,Bloch MH

更新日期：2018-06-08 00:00:00

abstract：:Neural oscillations and their interactions are associated with the coordination of neural groups, which provide a mechanism underlying information processing of brain functions. Notch1 receptor is involved in the neurological and psychiatric disorders, such as neurodevelopmental deficits, cerebral ischemia, Alzheimer'...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Li Q,Zhang X,Cheng N,Yang C,Zhang T

更新日期：2018-06-08 00:00:00

abstract：:Posttraumatic stress disorder (PTSD) is a debilitating condition highly comorbid with depression. The endocannabinoid (eCB) system and brain-derived neurotrophic factor (BDNF) are suggestively involved in both disorders. We examined whether cannabinoids can prevent the long-term depressive-like symptoms induced by exp...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Burstein O,Shoshan N,Doron R,Akirav I

更新日期：2018-06-08 00:00:00

abstract：:The complexity of the human brain emerges from a long and finely tuned developmental process orchestrated by the crosstalk between genome and environment. Vis à vis other species, the human brain displays unique functional and morphological features that result from this extensive developmental process that is, unsurp...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gabriele M,Lopez Tobon A,D'Agostino G,Testa G

更新日期：2018-06-08 00:00:00